Nelles M J, Streilein J W
Immunogenetics. 1980 Jul;11(1):75-86. doi: 10.1007/BF01567771.
The participation of hamster T cells in a variety of putative MHC-determined reactions was studied utilizing a well-characterized, highly selective goat anti-hamster thymocyte (G alpha HT) serum. Hamster lymphoid cell suspensions treated with G alpha HT lose much of their capacity to induce local graft-versus-host reactions and to function as responder cells in mixed lymphocyte reactions. In contrast to the participation of hamster T cells in alloimmune reactions (MLR and GVHR), virus-induced, cytotoxic activity in hamsters undergoing acute virus infection is not T-cell-mediated. This latter finding was rather surprising in view of the major role played by cytotoxic T effector cells in comparably infected mice and rats. These results suggest that, although hamsters are able to respond to putative class II MHC disparities in allogeneic reactions, MHC-encoded molecules, presumably class I, are not utilized for induction of effective cytotoxic activity in response to acute virus infection in this species. The implications of these findings are discussed in relation to our present understanding of the hamster MHC.
利用一种特性明确、高度特异的山羊抗仓鼠胸腺细胞（GαHT）血清，研究了仓鼠T细胞在各种假定的主要组织相容性复合体（MHC）决定的反应中的参与情况。用GαHT处理的仓鼠淋巴细胞悬液失去了大部分诱导局部移植物抗宿主反应以及在混合淋巴细胞反应中作为反应细胞发挥作用的能力。与仓鼠T细胞参与同种免疫反应（混合淋巴细胞反应和移植物抗宿主反应）形成对比的是，急性病毒感染仓鼠中由病毒诱导的细胞毒性活性并非由T细胞介导。鉴于细胞毒性T效应细胞在感染情况类似的小鼠和大鼠中发挥的主要作用，后一发现相当令人惊讶。这些结果表明，虽然仓鼠能够在同种异体反应中对假定的Ⅱ类MHC差异作出反应，但在该物种中，MHC编码的分子（大概是Ⅰ类）并未用于诱导针对急性病毒感染的有效细胞毒性活性。结合我们目前对仓鼠MHC的理解，讨论了这些发现的意义。
