Sokal J A, Barański B, Majka J, Rolecki R, Stetkiewicz J, Ivanova-Chemishanska L, Vergieva T, Antonov G, Mirkova E, Kolakowski J, Szendzikowski S, Wróblewska K
J Hyg Epidemiol Microbiol Immunol. 1980;24(3):285-94.
Male rats were exposed to vinyl chloride at the concentrations of 50, 500, and 20 000 ppm, 5 hours daily, 5 days a week for 10 months. Morphological lesions in the liver and the testes detected by light and electron microscope and depression in body weight increase intensified with the duration of exposure. Increased relative weights of some organs and slight hematological and biochemical changes in blood during the course of the experiment were also observed. Some toxic effects including morphological liver injuries arose at the smallest exposure level, i. e., 50 ppm. Assuming 50 ppm as the threshold concentration for rats, the 5 ppm level has been estimated as the safe exposure limit in industry in relation to systemic effects of vinyl chloride.
将雄性大鼠暴露于浓度为50、500和20000 ppm的氯乙烯环境中，每天5小时，每周5天，持续10个月。通过光学显微镜和电子显微镜检测到的肝脏和睾丸的形态学损伤以及体重增加的抑制随暴露时间的延长而加剧。在实验过程中还观察到一些器官相对重量增加以及血液中轻微的血液学和生化变化。在最低暴露水平即50 ppm时就出现了包括肝脏形态学损伤在内的一些毒性作用。假设50 ppm为大鼠的阈浓度，则估计5 ppm水平为工业中与氯乙烯全身效应相关的安全暴露限值。
