[患有45号肉瘤的大鼠在使用细胞抑制剂和利尿剂治疗过程中的造血指标]
[Hematopoietic indices in rats with sarcoma 45 in the process of treatment with cytostatics and diuretic agents].
作者信息
Pashinskiĭ V G, Sedova K S
出版信息
Vopr Onkol. 1978;24(3):83-6.
PMID:644969
Abstract
Sarcoma 45 growth in rats was noted to be followed by the development of anemia and leucocytosis. Sessional use of 6-mercaptopurine and cyclophosphane resulted in the enhancement of anemia, the development of leucopenia, and suppression of bone marrow hemopoiesis. The suppression of hemopoiesis was much less manifested, if cytostatics were used together with diuretics (diacarbe or furocemid).
摘要
肉瘤45在大鼠体内生长后，会出现贫血和白细胞增多的症状。长期使用6-巯基嘌呤和环磷酰胺会加重贫血，导致白细胞减少，并抑制骨髓造血功能。如果将细胞抑制剂与利尿剂（双醋碳酰胺或速尿）一起使用，造血抑制的表现则会轻得多。
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