van den Hende C, Muylle E, Vlaminck K, Oyaert W
Tijdschr Diergeneeskd. 1980 Dec 15;105(24):1054-9.
Both calcium ++-activated magnesium++ adenosine triphosphatase and the calcium++-accumulating activity of SR isolated from white skeletal muscle of pigs of the Yorkshire breed resistant to MH and pigs of the Belgian Landrace breed susceptible to MH continue to be stable throughout the process of growth. There was not any detectable difference between the two breeds and therefore it could not be concluded that there was a defective SR membrane. Abnormal contractions induced by halothane and caffeine in biopsy specimens of muscle of MH-susceptible pigs of the Belgian Landrace breed are mainly produced by external calcium++, CN--not having any inhibitory effect in these cases. The contractions induced by combined caffeine and halothane in susceptible animals are more marked than those occurring in resistant animals. These increased contractions are mainly due to external Ca++ and, to a less extent, to CN--sensitive mitochondrial Ca++ fluxes.
从抗恶性高热的约克夏猪和易患恶性高热的比利时长白猪的白色骨骼肌中分离出的钙激活镁腺苷三磷酸酶以及肌浆网的钙积累活性在整个生长过程中都保持稳定。这两个品种之间没有任何可检测到的差异，因此不能得出肌浆网膜存在缺陷的结论。在比利时长白猪这种易患恶性高热的猪的肌肉活检标本中，氟烷和咖啡因诱导的异常收缩主要由细胞外钙引起，在这些情况下氰化物没有任何抑制作用。在易感动物中，咖啡因和氟烷联合诱导的收缩比抗性动物中出现的收缩更明显。这些增强的收缩主要归因于细胞外钙，在较小程度上归因于对氰化物敏感的线粒体钙通量。
