Rastogi R K, Milone M, Chieffi G
Andrologia. 1980 Sep-Oct;12(5):476-81. doi: 10.1111/j.1439-0272.1980.tb01703.x.
The influence of cyproterone acetate (CA) (0.1 mg/mouse/day) on the epididymis and male fertility was analyzed in a long-term study in the Swiss albino cc strain. CA inhibits epididymal function in all segments as measured by organ weights, protein content and beta-glucuronidase activity. This antiandrogen also suppresses male fertility. It is important to note that the low dose of CA, used in this study, does not affect spermatogenesis. The effects of CA on epididymis and fertility are reversible and the magnitude of recovery or the period (in days) required for a significant recovery after the discontinuation of CA were seemingly directly proportional to the duration of antiandrogen treatment.
在一项针对瑞士白化cc品系小鼠的长期研究中，分析了醋酸环丙孕酮（CA）（0.1毫克/小鼠/天）对附睾及雄性生育能力的影响。通过器官重量、蛋白质含量和β-葡萄糖醛酸酶活性测定，CA可抑制附睾各节段的功能。这种抗雄激素药物还会抑制雄性生育能力。需要注意的是，本研究中使用的低剂量CA并不影响精子发生。CA对附睾和生育能力的影响是可逆的，停用CA后恢复的程度或显著恢复所需的时间（以天为单位）似乎与抗雄激素治疗的持续时间直接相关。
