Botsch H, Golde G, Kampf D
Rofo. 1980 Jun;132(6):713-5. doi: 10.1055/s-2008-1056649.
Theoretical volumes calculated from the reciprocal of the plasma concentration after intravenous injection of 131I-Iodohippurate were compared in 95 patients with clearance values calculated by the 2-compartment-method and in 18 patients with conventional PAH-clearance. For estimating Hippurate-clearance from a single blood sampling the most favorable time is 45 min. after injection (r = 0.96; clearance < 400/ml/min.: r = 0.98). Clearance values may be derived from the formula: C = 0.4 + 7.26 V - 0.021 . V2 (V = injected activity/activity per l plasma taken 45 min. after injection). The simplicity, precision and reproducibility of the above mentioned clearance-method is emphazised.
对95例采用二室模型法计算清除率的患者以及18例采用传统对氨基马尿酸清除率的患者，比较了静脉注射131I-碘马尿酸后根据血浆浓度倒数计算出的理论容积。为了通过单次血样估算马尿酸清除率，最适宜的时间是注射后45分钟（r = 0.96；清除率<400/ml/分钟：r = 0.98）。清除率值可由公式得出：C = 0.4 + 7.26V - 0.021V²（V = 注射活度/注射后45分钟采集的每升血浆中的活度）。强调了上述清除率方法的简便性、精确性和可重复性。
