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The pharmacokinetics and tumor and neural tissue penetrating properties of SR-2508 and SR-2555 in the dog--hydrophilic radiosensitizers potentially less toxic than misonidazole.

作者信息

White R A, Workman P, Brown J M

出版信息

Radiat Res. 1980 Dec;84(3):542-61.

PMID:6450431
Abstract
摘要

相似文献

1
The pharmacokinetics and tumor and neural tissue penetrating properties of SR-2508 and SR-2555 in the dog--hydrophilic radiosensitizers potentially less toxic than misonidazole.SR-2508和SR-2555在犬体内的药代动力学以及对肿瘤和神经组织的穿透特性——亲水性放射增敏剂，毒性可能低于甲硝唑。
Radiat Res. 1980 Dec;84(3):542-61.
2
Pharmacokinetics of hypoxic cell radiosensitizers: a review.乏氧细胞放射增敏剂的药代动力学：综述
Cancer Clin Trials. 1980 Fall;3(3):237-51.
3
Pharmacokinetics of the hypoxic radiosensitizers misonidazole and demethylmisonidazole after intraperitoneal administration in humans.低氧放射增敏剂米索硝唑和去甲基米索硝唑腹腔注射后在人体的药代动力学
Cancer Res. 1983 Feb;43(2):913-6.
4
The pharmacokinetics of misonidazole in the dog.灭滴灵在犬体内的药代动力学。
Eur J Cancer (1965). 1979 Oct;15(10):1233-42. doi: 10.1016/0014-2964(79)90249-4.
5
Misonidazole dose and tumor level relationships. Effects of individual variation in rate of misonidazole metabolism and absorption from the gastrointestinal tract.米索硝唑剂量与肿瘤水平的关系。米索硝唑代谢速率及从胃肠道吸收的个体差异的影响。
Cancer Clin Trials. 1981;4(1):41-6.
6
Concentrations achieved in human tumors after administration of misonidazole, SR-2508 and Ro 03-8799.给予米索硝唑、SR - 2508和Ro 03 - 8799后在人类肿瘤中达到的浓度。
Int J Radiat Oncol Biol Phys. 1986 Jul;12(7):1109-11. doi: 10.1016/0360-3016(86)90237-3.
7
Partition coefficient as a guide to the development of radiosensitizers which are less toxic than misonidazole.分配系数作为开发毒性低于米索硝唑的放射增敏剂的指导。
Radiat Res. 1980 Apr;82(1):171-90.
8
I.V. misonidazole (NSC 261037). Report of initial clinical experience.静脉注射米索硝唑（NSC 261037）。初步临床经验报告。
Cancer Clin Trials. 1981;4(1):33-9.
9
Pharmacokinetic and tumour-penetration properties of the hypoxic cell radiosensitizer desmethylmisonidazole (Ro 05-Ro-9963) in dogs.乏氧细胞放射增敏剂去甲基米索硝唑（Ro 05-Ro-9963）在犬体内的药代动力学及肿瘤穿透特性
Br J Cancer. 1980 Feb;41(2):268-76. doi: 10.1038/bjc.1980.39.
10
Comparison of the fate of misonidazole (RO 07-0582) and its metabolite desmethylmisonidazole (RO 05-9963), two hypoxic cell radiosensitizers: penetration properties in tumor bearing rats.两种乏氧细胞放射增敏剂米索硝唑（RO 07-0582）及其代谢产物去甲基米索硝唑（RO 05-9963）的转归比较：在荷瘤大鼠体内的渗透特性
J Pharmacol. 1983 Jan-Mar;14(1):67-77.

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Acquired factor V deficiency in the setting of mercaptopurine therapy for acute lymphoblastic leukemia.急性淋巴细胞白血病巯嘌呤治疗过程中获得性因子V缺乏症。
Ann Hematol. 2022 May;101(5):1137-1139. doi: 10.1007/s00277-021-04688-5. Epub 2021 Oct 6.
2
Nitroimidazoles and imaging hypoxia.硝基咪唑与缺氧成像
Eur J Nucl Med. 1995 Mar;22(3):265-80. doi: 10.1007/BF01081524.
3
Structure-pharmacokinetic relationships for misonidazole analogues in mice.米索硝唑类似物在小鼠体内的结构-药代动力学关系
Cancer Chemother Pharmacol. 1981;6(1):39-49. doi: 10.1007/BF00253009.
4
Enhancing effect of misonidazole on the response of the RIF-1 tumour to cyclophosphamide.米索硝唑对RIF-1肿瘤对环磷酰胺反应的增强作用。
Br J Cancer. 1981 Aug;44(2):208-18. doi: 10.1038/bjc.1981.172.
5
Preclinical pharmacokinetics of benznidazole.苄硝唑的临床前药代动力学
Br J Cancer. 1984 Sep;50(3):291-303. doi: 10.1038/bjc.1984.176.
6
Response of murine tumours to combinations of CCNU with misonidazole and other radiation sensitizers.小鼠肿瘤对洛莫司汀与米索硝唑及其他辐射增敏剂联合用药的反应。
Br J Cancer. 1982 Feb;45(2):272-81. doi: 10.1038/bjc.1982.43.
7
Correlation of partitioning of nitroimidazoles in the n-octanol/saline and liposome systems with pharmacokinetic parameters and quantitative structure-activity relationships (QSAR).硝基咪唑类化合物在正辛醇/盐水和脂质体系统中的分配与药代动力学参数及定量构效关系（QSAR）的相关性。
Pharm Res. 1989 May;6(5):399-403. doi: 10.1023/a:1015931431817.
8
A new, potent 2-nitroimidazole nucleoside hypoxic cell radiosensitizer, RP170.一种新型强效2-硝基咪唑核苷类乏氧细胞放射增敏剂，RP170。
Jpn J Cancer Res. 1989 Nov;80(11):1113-8. doi: 10.1111/j.1349-7006.1989.tb02267.x.
9
KIH-802, an acetohydroxamic acid derivative of 2-nitroimidazole, as a new potent hypoxic cell radiosensitizer: radiosensitizing activity, acute toxicity, and pharmacokinetics.KIH-802，一种2-硝基咪唑的乙酰氧肟酸衍生物，作为一种新型强效低氧细胞放射增敏剂：放射增敏活性、急性毒性及药代动力学
Cancer Chemother Pharmacol. 1990;26(2):112-6. doi: 10.1007/BF02897255.
10
2-Nitroimidazole potentiation of nitrosourea induced cytotoxicity in subcutaneous implants of rat 9L brain tumor cells.2-硝基咪唑增强亚硝基脲对大鼠9L脑肿瘤细胞皮下植入物的细胞毒性作用。
J Neurooncol. 1991 Aug;11(1):17-25. doi: 10.1007/BF00166993.