Grekin R J, Sider R S
Endocrinology. 1981 Jan;108(1):109-12. doi: 10.1210/endo-108-1-109.
Type I aldosterone receptors were measured in rat kidney cytosol preparations after alterations in dietary sodium and aldosterone injection. Changes in sodium intake had no effect on receptor number or affinity in adrenalectomized rats. Intact rats had decreased receptor numbers after a low sodium diet compared to those after a high sodium diet (P less than 0.005), and the decrease in receptor number was significantly correlated with the corresponding rise in serum aldosterone (r = -0.65; P less than 0.01). In adrenalectomized rats, injection of aldosterone was associated with a decrease in receptor number, and serum aldosterone correlated inversely with receptor number (r = 0.64; P less than 0.01). We conclude that increases in serum aldosterone decrease the number of available cytoplasmic aldosterone receptors, but changes in sodium intake have no direct effect upon aldosterone receptor number or affinity.
在改变饮食钠含量并注射醛固酮后，对大鼠肾细胞溶质制剂中的I型醛固酮受体进行了测量。钠摄入量的改变对肾上腺切除大鼠的受体数量或亲和力没有影响。与高钠饮食后的大鼠相比，低钠饮食后的完整大鼠受体数量减少（P<0.005），且受体数量的减少与血清醛固酮相应升高显著相关（r = -0.65；P<0.01）。在肾上腺切除大鼠中，注射醛固酮与受体数量减少有关，血清醛固酮与受体数量呈负相关（r = 0.64；P<0.01）。我们得出结论，血清醛固酮增加会减少可用细胞质醛固酮受体的数量，但钠摄入量的改变对醛固酮受体数量或亲和力没有直接影响。
