Gschnait F, Ita E
Wien Klin Wochenschr. 1978 Apr 28;90(9):309-11.
Hyperuicaemia is a frequent finding in psoriasis vulgaris. Enhanced purine catabolism due to the rapid turnover of psoriatric epidermis is thought to be the cause of the raised serum uric acid levels. In the present study serum acid determinations were performed in 197 patients with psoriasis vulgaris. Since no correlation was found between the extent of skin involvement and the incidence of hyperuricaemia, increased epidermopoesis does not seem to be an adequate explanation for hyperuricaemia in psoriasis. An analysis of body weight and serum cholesterol and triglyceride levels in psoriatic patients points to a combination of genetic predisposition and overeating as the causes of hyperuricaemia.
高尿酸血症在寻常型银屑病中很常见。由于银屑病表皮更新迅速导致嘌呤分解代谢增强,被认为是血清尿酸水平升高的原因。在本研究中,对197例寻常型银屑病患者进行了血清尿酸测定。由于未发现皮肤受累程度与高尿酸血症发生率之间存在相关性,表皮生成增加似乎并不能充分解释银屑病中的高尿酸血症。对银屑病患者体重、血清胆固醇和甘油三酯水平的分析表明,遗传易感性和暴饮暴食共同导致了高尿酸血症。