Asch R H, Siler-Khodr T M, Smith C G, Schally A V
J Clin Endocrinol Metab. 1981 Mar;52(3):565-71. doi: 10.1210/jcem-52-3-565.
A potent agonist of luteinizing hormone, D-Trp6-LRH, was administered at different stages during the luteal phase of rhesus monkeys (Macaca mulatta). Luteolysis, evidenced by short luteal phases and decreased serum progesterone concentrations, was consistently induced when the analog was injected on days 3 or 5 post ovulation; however, no effect was observed when it was given on day 7 post ovulation. Increasing doses of hCG administered from days 6-10 post ovulation prevented the luteolytic effect of D-Trp6-LRH. The possible mechanisms of action and the potential uses of LRH analogs as contraceptive agents are discussed.
给恒河猴（猕猴）黄体期的不同阶段注射促黄体生成素的强效激动剂D-色氨酸6-促黄体素释放激素（D-Trp6-LRH）。当在排卵后第3天或第5天注射该类似物时，始终会诱发黄体溶解，表现为黄体期缩短和血清孕酮浓度降低；然而，在排卵后第7天注射时未观察到效果。排卵后第6至10天给予递增剂量的人绒毛膜促性腺激素（hCG）可防止D-Trp6-LRH的黄体溶解作用。文中讨论了促黄体素释放激素（LRH）类似物作为避孕药的可能作用机制和潜在用途。
