Hoyme H E, Higginbottom M C, Jones K L
J Pediatr. 1981 Feb;98(2):228-31. doi: 10.1016/s0022-3476(81)80640-3.
Recognition of the disruptive vascular nature of the structural defects associated with gastroschisis and an appreciation of the embryology of the umbilical region suggest that gastroschisis results from an intrauterine interruption of the omphalomesenteric artery. This mechanism accounts for the usual location of gastroschisis to the right of the umbilical cord, the integrity of the rectus muscles in affected children, and many of the clinically observed differences between gastroschisis and omphalocele. The vascular basis of this defect explains its negligible recurrence risk and should alert the clinician to the possibility of concomitant structural defects of a similar pathogenesis.
认识到与腹裂相关的结构缺陷具有破坏性的血管本质，并了解脐区的胚胎学，提示腹裂是由于脐肠系膜动脉在子宫内中断所致。这一机制解释了腹裂通常位于脐带右侧的位置、患病儿童腹直肌的完整性，以及临床上观察到的腹裂与脐膨出之间的许多差异。这种缺陷的血管基础解释了其可忽略不计的复发风险，并应提醒临床医生注意可能存在的类似发病机制的伴随结构缺陷。
