Universidad del Valle, Facultad de Salud, Escuela de Ciencias Básicas, Departamento de Morfología, Cali, Colombia.
Colomb Med (Cali). 2021 Sep 30;52(3):e4004227. doi: 10.25100/cm.v52i3.4227. eCollection 2021 Jul-Sep.
gastroschisis is a congenital structural defect of the abdominal wall, most often to the right of the umbilicus, through which the abdominal viscera protrude. Its developmental, etiological and epidemiological aspects have been a hot topic of controversy for a long time. However, recent findings suggest the involving of genetic and chromosomal alterations and the existence of a stress-inducing pathogenetic pathway, in which risk factors such as demographic and environmental ones can converge. To expand the frontier of knowledge about a malformation that has showed a growing global prevalence, we have conducted a review of the medical literature that gathers information on the embryonic development of the ventral body wall, the primitive intestine, and the ring-umbilical cord complex, as well as on the theories about its origin, pathogenesis and recent epidemiological evidence, for which we consulted bibliographic databases and standard search engines.
先天性腹壁结构缺陷，脐旁右侧多见，内脏膨出。其发生发展、病因及流行病学方面一直是争议的热点。但最近的研究提示涉及遗传和染色体改变，存在一个应激诱导的发病途径，其中人口统计学和环境等危险因素可能汇聚。为了扩展对这种畸形的认识，我们对医学文献进行了综述，收集了有关腹侧体壁、原始肠和脐环复合体的胚胎发育，以及其起源、发病机制和最近的流行病学证据的信息，为此我们查阅了文献数据库和标准搜索引擎。
