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日粮添加方式对氯化汞在日本鹌鹑体内毒性的影响

Toxicity of mercuric chloride in Japanese quail as affected by methods of incorporation into the diet.

作者信息

El-Begearmi M M, Ganther H E, Sunde M L

出版信息

Poult Sci. 1980 Oct;59(10):2216-20. doi: 10.3382/ps.0592216.

DOI:10.3382/ps.0592216
PMID:6450952
Abstract

Three experiments were conducted with day-old Japanese quail. When mercuric chloride (HgCl2) was added to the diet as a dry salt, it produced higher mortality than when added as a solution or as a casein-premix. Averages of mortality at 4 weeks were 86%, 55%, and 33% when 500 ppm mercury as HgCl2 was added dry, in 95% ethanol, or as a casein-premix, respectively. The nature of solvent (ethanol, methanol, or water) had little or no effect. The addition of mercury as a HgCl2-casein premix produced the lowest mortality but increased the mercury content of the kidney. This suggests that casein did not reduce mortality by decreasing mercury absorption. A complete explanation of the phenomenon is not available at this time. Possibly, the solvent could facilitate the binding of mercury to some feed component, thereby affecting the mercury absorption, transport, and subsequent tissue distribution and making mercury less available to exert its toxicity.

摘要

对一日龄日本鹌鹑进行了三项实验。当将氯化汞(HgCl₂)作为干盐添加到饲料中时,其导致的死亡率高于以溶液形式或酪蛋白预混物形式添加时的情况。当以干盐形式添加500 ppm汞(以HgCl₂计)、以95%乙醇溶液形式添加或以酪蛋白预混物形式添加时,4周龄时的平均死亡率分别为86%、55%和33%。溶剂(乙醇、甲醇或水)的性质影响很小或没有影响。以HgCl₂ - 酪蛋白预混物形式添加汞导致的死亡率最低,但会增加肾脏中的汞含量。这表明酪蛋白并非通过减少汞的吸收来降低死亡率。目前尚无法对该现象做出完整解释。可能是溶剂能够促进汞与某些饲料成分的结合,从而影响汞的吸收、运输以及随后的组织分布,使汞较难发挥其毒性作用。

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引用本文的文献

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Interaction of mercury and water deprivation on growth, feed consumption, and mortality in chickens.汞与水分剥夺对鸡生长、采食量及死亡率的相互作用。
Bull Environ Contam Toxicol. 1984 Sep;33(3):317-24. doi: 10.1007/BF01625550.
2
Onset of mercury toxicity in young chickens.
Arch Environ Contam Toxicol. 1985 Mar;14(2):193-6. doi: 10.1007/BF01055611.