Götz M, Popow C
Wien Klin Wochenschr. 1980 Sep 26;92(18):638-41.
The protective activity of DSCG was investigated in 18 children with established non-specific bronchial hyperreactivity induced by bronchial challenge with acetylcholine. Ipratropium bromide, the anticholinergic agent, was used for comparison. DSCG showed a statistically significant inhibitory action on the decrease in specific airway conductance. Besides the well-established inhibition of mast cell degranulation a direct action on cholinergic irritative receptors seems likely. Application of DSCG in immunologically ill-defined forms of bronchial asthma may be considered. As expected, the direct acetylcholine antagonist, ipratropium bromide, showed an overall protective effect.
在18名因乙酰胆碱支气管激发试验而确诊为非特异性支气管高反应性的儿童中，研究了色甘酸钠（DSCG）的保护活性。使用抗胆碱能药物异丙托溴铵作为对照。DSCG对特定气道传导率的降低具有统计学上显著的抑制作用。除了对肥大细胞脱颗粒的公认抑制作用外，其对胆碱能刺激受体可能也有直接作用。可以考虑将DSCG应用于免疫界定不明确的支气管哮喘形式。正如预期的那样，直接乙酰胆碱拮抗剂异丙托溴铵显示出全面的保护作用。
