Meggyessy V, Révhelyi M, Méhes K
Acta Paediatr Acad Sci Hung. 1980;21(2-3):175-80.
The frequency of minor malformations was determined in 246 mentally retarded children with an I. Q. ranging from 37 to 67. According to the probable aetiology, the patients were divided into 4 groups: Down syndrome (n = 29), other genetic causes (n = 22), perinatal and postnatal environmental damages (n = 68), and unknown aetiology (n = 127). One thousand consecutive newborn infants served as controls. The mean number of minor malformations per subject was the highest in patients with Down syndrome (3.38) and other genetic disorders (2.00). It was significantly lower in the mentally handicapped of unknown (0.88) and of environmental origin (0.37). The number of multiple minor anomalies was high in the genetically determined conditions and the smallest and nearing the control value in the exogenic group. The results support the idea that the presence of minor malformations, and especially of multiple ones, refers to the prenatal onset of mental deficiency.
对246名智商在37至67之间的智障儿童进行了轻微畸形频率的测定。根据可能的病因，将患者分为4组：唐氏综合征（n = 29）、其他遗传原因（n = 22）、围产期和产后环境损害（n = 68）以及病因不明（n = 127）。1000名连续出生的新生儿作为对照。唐氏综合征患者（3.38）和其他遗传疾病患者（2.00）中，每位受试者的轻微畸形平均数最高。病因不明（0.88）和环境因素导致的智障患者中该平均数显著较低（0.37）。在遗传决定的情况下，多发轻微异常的数量较高，而在外源性组中数量最少且接近对照值。结果支持这样一种观点，即轻微畸形尤其是多发轻微畸形的存在与智力缺陷的产前发病有关。
