Weissbrod J M, Jain R K
J Pharm Sci. 1980 Jun;69(6):691-4. doi: 10.1002/jps.2600690621.
A mathematical model for streptozocin metabolism in mice is presented. By using the available bioassay and chemical assay data for a 300-mg/kg ip injection and the principles of physiologically based pharmacokinetics, a membrane-limited transport model with first-order kinetics was found to simulate the data adequately (average error of less than 20%). Furthermore, the first-order reaction constant derived in analyzing the bioassay data (0.009 min-1) was in close agreement with the half-life of streptozocin (1 hr) reported previously.
本文提出了一种小鼠体内链脲佐菌素代谢的数学模型。通过使用300mg/kg腹腔注射的现有生物测定和化学测定数据以及基于生理的药代动力学原理，发现具有一级动力学的膜限制转运模型能够充分模拟数据（平均误差小于20%）。此外，在分析生物测定数据时得出的一级反应常数（0.009 min-1）与先前报道的链脲佐菌素半衰期（1小时）非常吻合。
