Gloor M, Lamerz A, Franke-Hoffman M
Zentralbl Bakteriol A. 1981 Feb;248(4):502-8.
Investigations are reported which attempt to contribute towards an understanding of those cases in which topical treatment with erythromycin is unsuccessful. In 13 acne patients no resistance of P. acnes was observed after seven weeks of topical treatment with erythromycin. This demonstrates that the 20% frequency of resistance induction reported in the literature is too high. In the 13 treated patients there was no essential reduction in the number of inflammatory lesions although a decrease in the number of Propionibacteria in the pilosebaceous ducts occurred. This result is perhaps connected with a concurrent increase in Micrococcaceae, which could suggest that not only Propionibacteria, but also Micrococcaceae play a role in the pathogenesis of acne.
本文报告了一些调查研究，旨在帮助理解那些局部使用红霉素治疗失败的病例。对13名痤疮患者进行了局部使用红霉素治疗7周的研究，未观察到痤疮丙酸杆菌产生耐药性。这表明文献中报道的20%的耐药诱导频率过高。在这13名接受治疗的患者中，炎性皮损数量虽未显著减少，但毛囊皮脂腺导管中的丙酸杆菌数量有所下降。这一结果可能与微球菌科数量的同时增加有关，这表明不仅丙酸杆菌，微球菌科在痤疮发病机制中也起作用。
