链脲佐菌素对胰岛细胞的体外、性别依赖性及直接细胞毒性作用。 - Suppr | 超能文献

An in vitro, sex dependents, and direct cytotoxic effect of streptozotocin on pancreatic islet cells.

作者信息

Kromann H, Christy M, Lernmark A, Nerup J

出版信息

Horm Metab Res. 1981 Feb;13(2):120-1. doi: 10.1055/s-2007-1019191.

DOI:10.1055/s-2007-1019191

Abstract

摘要

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An in vitro, sex dependents, and direct cytotoxic effect of streptozotocin on pancreatic islet cells.链脲佐菌素对胰岛细胞的体外、性别依赖性及直接细胞毒性作用。

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KATP channel-deficient pancreatic beta-cells are streptozotocin resistant because of lower GLUT2 activity.由于葡萄糖转运蛋白2（GLUT2）活性较低，ATP敏感性钾通道缺陷型胰腺β细胞对链脲佐菌素具有抗性。

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Islet generation from intra islet precursor cells of diabetic pancreas: in vitro studies depicting in vivo differentiation.源自糖尿病胰腺胰岛内前体细胞的胰岛生成：描述体内分化的体外研究。

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DNA synthesis in pancreatic islet and acinar cells in rats with streptozotocin-induced diabetes.链脲佐菌素诱导糖尿病大鼠胰岛和腺泡细胞中的DNA合成

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Simvastatin protects against multiple low-dose streptozotocin-induced type 1 diabetes in CD-1 mice and recurrence of disease in nonobese diabetic mice.辛伐他汀可预防CD-1小鼠中多次低剂量链脲佐菌素诱导的1型糖尿病，并预防非肥胖糖尿病小鼠的疾病复发。

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引用本文的文献

1

Multiple low-dose streptozotocin-induced hyperglycemia and insulitis in C57BL mice: influence of inbred background, sex, and thymus.多次低剂量链脲佐菌素诱导的C57BL小鼠高血糖和胰岛炎：近交系背景、性别和胸腺的影响

Proc Natl Acad Sci U S A. 1982 Jan;79(2):630-4. doi: 10.1073/pnas.79.2.630.

2

The low dose streptozotocin murine model of type 1 (insulin-dependent) diabetes mellitus: studies in vivo and in vitro of the modulating effect of sex hormones.1型（胰岛素依赖型）糖尿病的低剂量链脲佐菌素小鼠模型：性激素调节作用的体内和体外研究

Diabetologia. 1982 Mar;22(3):194-8. doi: 10.1007/BF00283752.