Kamenetskiĭ V K
Zh Nevropatol Psikhiatr Im S S Korsakova. 1978;78(3):365-70.
The paper is concerned with a study of the effect of metamizil in 45 patients with different forms of vascular parkinsonism. It was established that metamizil exerts a positive effect on the development of neurological symptoms (rigidity, bradykinesia, tremor) in mild and moderately expressed degrees of lesions. In most of the cases the drugs appeared effective in doses of 0.001 g thrice daily, and in separate cases 0.001 g 6 times daily. In the majority of patients metazil was tolerated without significant side effects. In some patients the side effects (vertigo, dryness in the mouth) were slightly expressed. The effect of treatment was seen after 2 days up to 2 weeks and lasted during the whole course of treatment and sometimes after it. Metamizil possessing a moderate sedative action, as well as spasmolytical and hypotensive is indicated for patients with vascular parkinsonism.
该论文关注对45例不同类型血管性帕金森病患者使用安乃近的疗效研究。结果表明,安乃近对轻度和中度病变程度的神经症状(僵硬、运动迟缓、震颤)的发展具有积极作用。在大多数情况下,药物每日三次、每次0.001克的剂量有效,个别情况下每日六次、每次0.001克有效。大多数患者对安乃近耐受性良好,无明显副作用。部分患者有轻微的副作用(眩晕、口干)。治疗效果在2天至2周后显现,并在整个治疗过程中持续,有时在治疗后仍持续。安乃近具有适度的镇静作用以及解痉和降压作用,适用于血管性帕金森病患者。