Broder S, Uchiyama T, Muul L M, Goldman C, Sharrow S, Poplack D G, Waldmann T A
N Engl J Med. 1981 Jun 4;304(23):1382-7. doi: 10.1056/NEJM198106043042302.
We studied the suppressor activity and surface-membrane antigens of immunoregulatory neoplastic T cells from a child with acute lymphoblastic leukemia and hypogammaglobulinemia. The neoplastic T cells were potent inhibitors of immunoglobulin production by pokeweed-mitogen-stimulated normal B cells when radiosensitive cooperative normal T cells were present. Preculturing the leukemic cells with normal T cells or soluble factors allowed them to mediate suppression without the need for cooperating T cells. While acquiring new functional capabilities, approximately 95 per cent of the leukemic cells displayed an antigen (OKT-3) that is found on mature normal T cells; 77 per cent displayed an antigen (Tac) that is found on normal activated immunoregulatory effector cells but not on thymocytes or circulating T cells that are precursors of these effector cells. The results suggest that a population of leukemic prosuppressor cells can be induced to undergo both functional and antigenic differentiation by the influence of normal T cells.
我们研究了一名患有急性淋巴细胞白血病和低丙种球蛋白血症儿童的免疫调节性肿瘤T细胞的抑制活性和表面膜抗原。当存在对辐射敏感的协同正常T细胞时，肿瘤T细胞是商陆丝裂原刺激的正常B细胞产生免疫球蛋白的有效抑制剂。用正常T细胞或可溶性因子预培养白血病细胞，可使其在无需协同T细胞的情况下介导抑制作用。在获得新的功能能力的同时，约95%的白血病细胞显示出成熟正常T细胞上存在的一种抗原（OKT-3）；77%的细胞显示出正常活化的免疫调节效应细胞上存在但胸腺细胞或这些效应细胞前体的循环T细胞上不存在的一种抗原（Tac）。结果表明，正常T细胞的影响可诱导一群白血病前抑制细胞发生功能和抗原分化。
