Wheeler G P, Schabel F M, Trader M W
Cancer Treat Rep. 1981 Jul-Aug;65(7-8):591-9.
A rationale based on known chemical, biochemical, and biologic properties of nitrosoureas led to the testing of combinations of CCNU with chlorozotocin for in vivo activity against L1210 leukemia. Several combinations yielded synergistic antileukemic activity.
基于亚硝基脲已知的化学、生物化学和生物学特性的理论依据，促使人们对洛莫司汀与氯脲霉素联合用药针对L1210白血病的体内活性进行测试。几种联合用药产生了协同抗白血病活性。
