D-色氨酸-6-促黄体生成素释放激素未能中断人类已建立的妊娠。

Failure to interrupt established pregnancy in humans by D-tryptophan-6-luteinizing hormone-releasing hormone.

作者信息

Tolis G, Comaru-Schally A M, Mehta A E, Schally A V

出版信息

Fertil Steril. 1981 Aug;36(2):241-2. doi: 10.1016/s0015-0282(16)45688-8.

Abstract

Four women 5 to 8 weeks into pregnancy, scheduled for therapeutic abortions, were given an analog of gonadotropin-releasing hormone, D-tryptophan-6-LHRH, in an effort to interrupt pregnancy. The treatment consisted of 100-micrograms injections, given twice daily for 5 to 10 days. No decline in serum beta-hCG or progesterone was noted, and menstrual extraction was needed in all women for pregnancy interruption. These data indicate that D-Trp-6-LHRH is not effective as an abortifacient in established pregnancy.

摘要

四名怀孕5至8周、计划进行治疗性流产的女性，被给予促性腺激素释放激素类似物D-色氨酸-6-促黄体生成素释放激素（D-tryptophan-6-LHRH），以尝试终止妊娠。治疗方法为每日注射100微克，持续5至10天。未观察到血清β-人绒毛膜促性腺激素（β-hCG）或孕酮水平下降，所有女性均需进行刮宫术以终止妊娠。这些数据表明，D-色氨酸-6-促黄体生成素释放激素（D-Trp-6-LHRH）在已确诊的妊娠中作为堕胎药无效。