通过电泳检测小鼠中的突变体：丙卡巴肼模型诱导实验的结果
The detection of mutants in mice by electrophoresis: results of a model induction experiment with procarbazine.
作者信息
Johnson F M, Roberts G T, Sharma R K, Chasalow F, Zweidinger R, Morgan A, Hendren R W, Lewis S E
出版信息
Genetics. 1981 Jan;97(1):113-24. doi: 10.1093/genetics/97.1.113.
Abstract
Male mice of the DBA/2J strain were treated with the mutagen procarbazine and mated with C57BL/6J females. Offspring and parents were then analyzed for electrophoretically expressed mutations. A control group, not mutagen treated, was also examined. Two mutants probably due to induction were identified, and several of spontaneous origin were also found.
摘要
用诱变剂丙卡巴肼处理DBA/2J品系的雄性小鼠，并使其与C57BL/6J雌性小鼠交配。然后对后代和双亲进行电泳表达突变分析。同时也检测了未经过诱变剂处理的对照组。鉴定出两个可能由诱变产生的突变体，还发现了几个自发产生的突变体。
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