一项关于躁郁症与人类白细胞抗原、血型、血清蛋白及红细胞酶的连锁研究。

A linkage study of manic-depressive disorder with HLA antigens, blood groups, serum proteins and red cell enzymes.

作者信息

Johnson G F, Hunt G E, Robertson S, Doran T J

出版信息

J Affect Disord. 1981 Mar;3(1):43-58. doi: 10.1016/0165-0327(81)90018-5.

Abstract

Families with a two-generational history of affective disorder and well and ill sibs were selected from a population of bipolar manic-depressive patients and typed for HLA antigens, blood groups, serum proteins and red cell enzymes. Segregation of specific HLA alleles was not associated with affective illness across family pedigrees. Further, no significant associations were found between affective disorder and ABO, Rh, MNSs blood groups or Hp, EsD, C3, Gc or PGM. Using the lod score method of Morton (1955) for determining linkage, these data indicated that close linkage is unlikely for affective disorder and HLA alleles, haptoglobin, Rh factor, or ABO blood groups.

摘要

从双相躁狂抑郁症患者群体中选取有两代情感障碍病史且有患病和未患病兄弟姐妹的家庭，对其进行HLA抗原、血型、血清蛋白和红细胞酶分型。特定HLA等位基因在整个家族谱系中的分离与情感疾病无关。此外，在情感障碍与ABO、Rh、MNSs血型或Hp、EsD、C3、Gc或PGM之间未发现显著关联。使用莫顿（1955年）的对数优势比分法来确定连锁关系，这些数据表明情感障碍与HLA等位基因、触珠蛋白、Rh因子或ABO血型之间不太可能存在紧密连锁。