Targum S D, Gershon E S, Van Eerdewegh M, Rogentine N
Biol Psychiatry. 1979 Aug;14(4):615-36.
An association and linkage study of the HLA system and bipolar affective illness is reported. HLA B-14 showed an increased frequency and HLA-Bw27 a decreased frequency in 92 bipolar patients compared to 210 controls, but significance is not reached when appropriate statistical corrections are made. It is shown that ethnological differences can lead to sampling biases; a purported increased frequency of HLA-Bw 16 in Ashkenazi Jewish bipolar patients is negated when ethnologically similar controls are used. The transmission of HLA alleles in nine families with at least two generations of affective illness revealed independent assortment, and nonlinkage to either locus A or B was demonstrated using a multigenerational method of linkage analysis. The nonreplicability of the HLA association studies, and the failure to demonstrate linkage of the HLA loci with afe development of affective illness, although further analyses are necessary.
本文报道了一项关于HLA系统与双相情感障碍的关联及连锁研究。与210名对照相比，92名双相情感障碍患者中HLA B-14频率增加，HLA-Bw27频率降低，但在进行适当的统计校正后未达到显著水平。研究表明，种族差异可导致抽样偏差；当使用种族相似的对照时，阿什肯纳兹犹太双相情感障碍患者中所谓的HLA-Bw16频率增加被否定。对九个至少有两代情感障碍患者的家庭进行HLA等位基因传递分析，结果显示其呈独立分配，采用多代连锁分析方法证明其与A或B位点均无连锁关系。尽管还需要进一步分析，但HLA关联研究结果不可重复，且未证明HLA位点与情感障碍发病存在连锁关系。
