Lithium inhibition of phosphofructokinase.
作者信息
Kajda P K, Birch N J
出版信息
J Inorg Biochem. 1981 Jun;14(3):275-8. doi: 10.1016/s0162-0134(00)80008-2.
PMID:6455502
Abstract
The mode of action of lithium in prophylaxis of recurrent affective disorder is unknown although it has been suggested that lithium might compete with magnesium in magnesium dependent processes. We have previously shown pyruvate kinase to be inhibited by lithium and the present study demonstrates a small inhibition by lithium of phosphofructokinase that is also a major regulatory step in glycolysis. Inhibition of PFK was competitive with respect to ATP and magnesium and noncompetitive with respect to potassium and fructose-6-phosphate. Inhibition was enhanced at reduced concentrations of magnesium.
摘要
相似文献
1
Lithium inhibition of phosphofructokinase.
J Inorg Biochem. 1981 Jun;14(3):275-8. doi: 10.1016/s0162-0134(00)80008-2.
2
A mathematical model for the influence of fructose 6-phosphate, ATP, potassium, ammonium and magnesium on the phosphofructokinase from rat erythrocytes;果糖6-磷酸、ATP、钾、铵和镁对大鼠红细胞磷酸果糖激酶影响的数学模型；
Eur J Biochem. 1974 Nov 1;49(1):169-78. doi: 10.1111/j.1432-1033.1974.tb03822.x.
3
Kinetic studies of rabbit muscle phosphofructokinase.兔肌磷酸果糖激酶的动力学研究
Arch Biochem Biophys. 1972 Apr;149(2):361-8. doi: 10.1016/0003-9861(72)90334-7.
4
Rabbit muscle phosphofructokinase. A model for regulatory kinetic behavior.兔肌磷酸果糖激酶。调节动力学行为的一个模型。
J Biol Chem. 1979 Mar 25;254(6):1896-901.
5
Rabbit muscle phosphofructokinase. The kinetic mechanism of action and the equilibrium constant.兔肌磷酸果糖激酶。作用的动力学机制及平衡常数。
J Biol Chem. 1973 Nov 25;248(22):7852-9.
6
Rabbit muscle phosphofructokinase. II. Product and dead end inhibition.兔肌磷酸果糖激酶。II. 产物抑制和无效末端抑制
J Biol Chem. 1974 Feb 25;249(4):1271-6.
7
Studies on the fructose 1-phosphate kinase activity of rabbit muscle phosphofructokinase.兔肌磷酸果糖激酶的果糖-1-磷酸激酶活性研究。
J Biol Chem. 1972 Mar 25;247(6):1692-8.
8
Clotrimazole potentiates the inhibitory effects of ATP on the key glycolytic enzyme 6-phosphofructo-1-kinase.克霉唑增强了 ATP 对关键糖酵解酶 6-磷酸果糖-1-激酶的抑制作用。
Arch Biochem Biophys. 2010 May;497(1-2):62-7. doi: 10.1016/j.abb.2010.03.013. Epub 2010 Mar 25.
9
Properties of muscle phosphofructokinase of cold- and warm-acclimated Carassius auratus.冷适应和暖适应鲫鱼肌肉磷酸果糖激酶的特性
Comp Biochem Physiol B. 1971 Aug 15;39(4):747-64. doi: 10.1016/0305-0491(71)90100-3.
10
Inhibition of rat liver phosphofructokinase-2 by phosphoenolpyruvate and ADP.磷酸烯醇丙酮酸和ADP对大鼠肝脏磷酸果糖激酶-2的抑制作用。
Biochem Biophys Res Commun. 1984 Nov 14;124(3):793-6. doi: 10.1016/0006-291x(84)91027-1.
引用本文的文献
1
Mood stabilizers target cellular plasticity and resilience cascades: implications for the development of novel therapeutics.情绪稳定剂作用于细胞可塑性和恢复力级联反应：对新型疗法开发的启示。
Mol Neurobiol. 2005 Oct;32(2):173-202. doi: 10.1385/MN:32:2:173.
Zotero 插件