[Immunomorphologic analysis of G2-chalone localization in epidermal-type tissues].

Localization of the epidermal G2-chalone in tissues has been established by means of indirect method of Coons using a monospecific immune serum. It has been found in dermal epithelia of the back, external ear, tongue, esophagus, forestomach, vagina, hairy follicles, but it has not been found in the sebaceous glands and derma. These findings are fully in agreement with the results obtained by the method of double diffusion after Ouchterlony. Tissue specificity of G2-chalone is proved by the fact that at places where epithelia differing histogenetically join with each other, it is found only in the epithelia of the epidermal type. Within the epithelial layer G2-chalone is mainly localized in the spinous and partly in the basal cells. Possible mechanisms on regulation of the mitotic activity are discussed in connection with the data obtained.