Puizillout J J, Gaudin-Chazal G, Sayadi A, Vigier D
J Physiol (Paris). 1981;77(2-3):415-24.
Serotoninergic neurons play a critical role in the sleep mechanism. This is supported by a lot of converging experiments and has provided the basis for a great deal of research. A critical analysis is first developed, supported by more recent data which are not in complete agreement with the theory that raphe nuclei are actively implied in slow wave sleep. On the other hand, numerous experimental evidences were collected during the sixties on the EEG synchronizing influence of the lower brain stem and preoptic area. Recent data showed that serotonin could also play here a crucial role in the induction of sleep. Nevertheless, at the moment, it is difficult to make a critical examination of the interaction and regulation of these putative 5-HT-related areas of the brain, but we can postulate that the occurrence of true physiological sleep-waking continuum necessitates their successive or conjoint activation.
血清素能神经元在睡眠机制中起着关键作用。这得到了许多相互印证的实验的支持，并为大量研究提供了基础。首先进行了批判性分析，近期数据对中缝核积极参与慢波睡眠这一理论并不完全认同，此分析受这些数据支持。另一方面，在60年代收集了大量关于脑干下部和视前区对脑电图同步影响的实验证据。近期数据表明，血清素在这里对睡眠诱导也可能起着关键作用。然而，目前很难对这些假定的与5-羟色胺相关的脑区之间的相互作用和调节进行批判性审视，但我们可以推测，真正的生理睡眠-觉醒连续体的出现需要它们相继或共同激活。
