Wall J R, Chartier B
J Clin Lab Immunol. 1981 Sep;6(2):115-9.
Blood T lymphocytes with suppressor activity [stable T cells, low affinity T cells and T cells with Fc receptors for IgG (T gamma cells)] were enumerated, using rosette tests, in patients with Graves' hyperthyroidism, Hashimoto's thyroiditis, silent thyroiditis, primary hypothyroidism, Graves' ophthalmopathy and subacute thyroiditis. General suppressor function, assessed as inhibition of pokeweed mitogen induced plasma cell generation by concanavalin-A stimulated T cells was measured in patients with Graves' hyperthyroidism, Hashimoto's thyroiditis and subacute thyroiditis. Suppressor T cell numbers were found to be essentially normal in patients with Graves' hyperthyroidism, Hashimoto's thyroiditis, Graves' ophthalmopathy, silent thyroiditis and hypothyroidism, although % T gamma cells were increased in 5 of the 7 patients with subacute thyroiditis tested. Suppressor cell function was normal in patients with graves' hyperthyroidism, Hashimoto's thyroiditis and subacute thyroiditis. It is likely that the putative deficiency of suppressor T cells in thyroid autoimmunity is restricted to a few clones of cells allowing retention of thyroid directed effector cells. The mechanism for increased T gamma cells in subacute thyroiditis is unclear although likely to reflect either a physiological response to sensitization following thyroid antigen release or a non-specific effect of the viral infection.
运用玫瑰花结试验，对患有格雷夫斯甲状腺功能亢进症、桥本甲状腺炎、寂静性甲状腺炎、原发性甲状腺功能减退症、格雷夫斯眼病和亚急性甲状腺炎的患者，进行具有抑制活性的血液T淋巴细胞（稳定T细胞、低亲和力T细胞以及具有IgG Fc受体的T细胞（Tγ细胞））计数。在患有格雷夫斯甲状腺功能亢进症、桥本甲状腺炎和亚急性甲状腺炎的患者中，测定总体抑制功能，评估为通过伴刀豆球蛋白A刺激的T细胞对商陆有丝分裂原诱导的浆细胞生成的抑制作用。发现格雷夫斯甲状腺功能亢进症、桥本甲状腺炎、格雷夫斯眼病、寂静性甲状腺炎和甲状腺功能减退症患者的抑制性T细胞数量基本正常，尽管在7例接受检测的亚急性甲状腺炎患者中有5例的Tγ细胞百分比增加。格雷夫斯甲状腺功能亢进症、桥本甲状腺炎和亚急性甲状腺炎患者的抑制细胞功能正常。甲状腺自身免疫中假定的抑制性T细胞缺陷可能仅限于少数细胞克隆，从而使甲状腺定向效应细胞得以保留。亚急性甲状腺炎中Tγ细胞增加的机制尚不清楚，尽管可能反映了甲状腺抗原释放后对致敏的生理反应或病毒感染的非特异性效应。
