Vonderheid E C, Dellatorre D L, Van Scott E J
Arch Dermatol. 1981 Sep;117(9):586-9.
A patient with slowly progressive tumor-stage mycosis fungoides (MF), without apparent extracutaneous involvement, received topical immunotherapy with mechlortethamine hydrochloride as the immunogen. A complete remission was achieved after two months of treatment, and the patient has remained free of detectable disease without further treatment for more than seven years. This case is also unusual in that, before treatment, a temporary exacerbation of MF had occurred during three pregnancies. These observations suggest that the natural resistance against the progression of MF in this patient was enhanced by immunotherapy.
一名患有缓慢进展性肿瘤期蕈样肉芽肿（MF）且无明显皮肤外受累的患者，接受了以盐酸氮芥为免疫原的局部免疫治疗。治疗两个月后实现了完全缓解，且该患者在未进一步治疗的情况下已超过七年未检测到疾病。该病例的不同寻常之处还在于，在治疗前，MF在三次怀孕期间曾出现暂时加重。这些观察结果表明，免疫治疗增强了该患者对MF进展的天然抵抗力。
