Abrahamsson L, Hackl H, Lindström B, Sogn J
Wien Klin Wochenschr. 1981 Sep 18;93(17):552-6.
76 women with virilizing features (68 women suffering from hirsutism and 8 from acne) were treated on average for 25 months according to different models of Androcur medication. Success of treatment was clinically assessed as good in 3/4 of the cases and slight in the remaining 1/4. However, treatment is more successful in cases of adrenal hirsutism than in idiopathic hirsutism. Moreover, success of treatment seems to be better in women below 35 than over 35 years of age. Side effects, mostly bleeding anomalies and fatigue, were found in 31 women; these must be attributed to the gestagenic component of cyproterone acetate. By contrast, 12 women showed positive side effects such as weight reduction, improvement in depression states and reversal of hair loss, which must be attributed to the antiandrogenic component. The selected continuation rate in all subjects was 86% and the unselected 72%, over a treatment period of 4.5 years. Furthermore, hormonal controls were carried out under treatment. These showed, on average, a depression of plasma androstendione of 17%, of total plasma testosterone of 47%, as well as an inhibition of the testosterone/sex hormone-binding globulin quotient of 58%. These inhibition effects speak in favour of alterations taking place in steroid metabolism. However, by inhibition of androgenic serum levels, the mechanism of cyproterone acetate is only assisted, while the main mechanism is based on peripheral receptor inhibition. Furthermore, as additional component in this action a slight increase in plasma binding capacity was found during combined cyproterone-oestrogen treatment.
76名具有男性化特征的女性（68名多毛症女性和8名痤疮女性）根据不同的醋酸环丙孕酮用药模式平均接受了25个月的治疗。治疗成功在3/4的病例中临床评估为良好，其余1/4为轻微。然而，肾上腺性多毛症的治疗比特发性多毛症更成功。此外，35岁以下女性的治疗成功率似乎高于35岁以上女性。在31名女性中发现了副作用，主要是出血异常和疲劳；这些副作用必须归因于醋酸环丙孕酮的孕激素成分。相比之下，12名女性出现了积极的副作用，如体重减轻、抑郁状态改善和脱发逆转，这必须归因于抗雄激素成分。在4.5年的治疗期间，所有受试者的选定持续率为86%，未选定的为72%。此外，在治疗期间进行了激素检查。这些检查平均显示血浆雄烯二酮降低了17%，总血浆睾酮降低了47%，以及睾酮/性激素结合球蛋白商抑制了58%。这些抑制作用表明类固醇代谢发生了变化。然而，通过抑制雄激素血清水平，醋酸环丙孕酮的作用机制只是得到了辅助，而主要机制是基于外周受体抑制。此外，在醋酸环丙孕酮 - 雌激素联合治疗期间，作为该作用的额外成分，发现血浆结合能力略有增加。
