在兔实验性感染中比较脲基青霉素与西索米星及头孢噻吩的治疗效果评估。

Evaluation of therapeutic efficacy of ureidopenicillins in comparison to sisomicin and cephalotin in experimental infections of rabbits.

作者信息

Dzierzanowska D, Klosinska E, Roszkowski W, Patzer J, Jeljaszewicz J

出版信息

Zentralbl Bakteriol Mikrobiol Hyg A Med Mikrobiol Infekt Parasitol. 1981 Sep;250(3):312-21.

Abstract

The therapeutic efficacy of azlocillin, mezlocillin, cephalotin, and sisomicin was evaluated by experimental infection in rabbits. After one hour following infection with Escherichia coli, Klebsiella pneumoniae or Pseudomonas aeruginosa, antibiotics were applied intramuscularly. Colony-forming units were counted before the infection and every day thereafter. Leukocytosis was determined before infection and 3 and 7 days after initiation of therapy. Therapy with antibiotics was continued for seven days, rabbits sacrificed and CFU/g tissue determined. It was shown that in experimental infection caused by E. coli or K. pneumoniae in rabbits, sisomicin was most effective, followed by mezlocillin, azlocillin, and cephalotin. Efficacy of therapy against P. aeruginosa was as follows: sisomicin, azlocillin, mezlocillin.

摘要

通过兔实验性感染评估了阿洛西林、美洛西林、头孢噻吩和西索米星的治疗效果。在用大肠杆菌、肺炎克雷伯菌或铜绿假单胞菌感染后1小时，肌肉注射抗生素。在感染前及之后每天计数菌落形成单位。在感染前以及治疗开始后3天和7天测定白细胞增多情况。抗生素治疗持续7天，处死兔子并测定每克组织中的菌落形成单位。结果表明，在兔大肠杆菌或肺炎克雷伯菌引起的实验性感染中，西索米星最有效，其次是美洛西林、阿洛西林和头孢噻吩。抗铜绿假单胞菌的治疗效果如下：西索米星、阿洛西林、美洛西林。