肾功能衰竭患者及血液透析期间莫西拉坦的药代动力学
Pharmacokinetics of moxalactam in patients with renal failure and during hemodialysis.
作者信息
Srinivasan S, Neu H C
出版信息
Antimicrob Agents Chemother. 1981 Sep;20(3):398-400. doi: 10.1128/AAC.20.3.398.
Abstract
The pharmacokinetics of moxalactam were determined in eight patients with end stage renal disease who were undergoing chronic hemodialysis. The mean half-life of moxalactam in the interdialysis period was 19 h, with a range of 9 to 30 h. The mean half-life of moxalactam during dialysis was 4 +/- 0.58 h. Serum levels of 30 +/- 10 micrograms/ml were present 24 h after a 1-g dose in the interdialysis period. A dose of 1 g at the end of each dialysis period in patients undergoing thrice-weekly hemodialysis would provide levels far in excess of the minimal inhibitory levels against Enterobacteriaceae.
摘要
测定了8例终末期肾病且正在接受慢性血液透析患者的拉氧头孢的药代动力学。透析间期拉氧头孢的平均半衰期为19小时，范围为9至30小时。透析期间拉氧头孢的平均半衰期为4±0.58小时。透析间期给予1g剂量后24小时血清水平为30±10μg/ml。对于每周进行三次血液透析的患者，在每次透析结束时给予1g剂量，其血药浓度将远远超过对肠杆菌科细菌的最低抑菌浓度。
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