全身照射对新生期胸腺切除小鼠的影响。良性和恶性肿瘤的发生率。
Effects of whole-body irradiation on neonatally thymectomized mice. Incidence of benign and malignant tumors.
作者信息
Anderson R E, Howarth J L, Troup G M
出版信息
Am J Pathol. 1978 May;91(2):217-27.
The individual and combined effects of neonatal thymectomy and whole-body irradiation on the prevalence of benign and malignant tumors in germ-free female mice of the Charles Rivers line were studied to determine if a portion of the tumorigenic effects of irradiation can be attributed to injury of the thymic-dependent component of the immune response. Neonatal thymectomy increased a) the incidence of benign and malignant tumors and b) the prevalence of multiple primary neoplasms in an individual mouse. Whole-body exposure to 700 rad at 6 weeks of age further increased th incidence of tumors, but the relative magnitude of this increase was less pronounced than in sham-operated controls. Thus, the cumulative effects of thymectomy plus irradiation are less pronounced than the sum of the individual effects. One of several possible explanations for this observation is that a portion of the carcinogenic effects of whole-body irradiation is mediated by suppression of the thymic-dependent component of the immune response.
研究了新生期胸腺切除和全身照射对无特定病原体的查尔斯河品系雌性小鼠良性和恶性肿瘤发生率的单独及联合影响，以确定照射致癌效应的一部分是否可归因于免疫反应中胸腺依赖成分的损伤。新生期胸腺切除增加了：a）良性和恶性肿瘤的发生率；b）单个小鼠中多发原发性肿瘤的患病率。6周龄时全身暴露于700拉德进一步增加了肿瘤发生率，但这种增加的相对幅度比假手术对照组要小。因此，胸腺切除加照射的累积效应不如单独效应之和明显。对此观察结果的几种可能解释之一是，全身照射的致癌效应一部分是由免疫反应中胸腺依赖成分的抑制介导的。
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