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本文引用的文献

1
EFFECT OF EARLY THYMECTOMY ON DEVELOPMENT OF MAMMARY TUMOURS IN MICE.早期甲状腺切除术对小鼠乳腺肿瘤发生发展的影响。
Nature. 1964 Sep 12;203:1188. doi: 10.1038/2031188a0.
2
Cancer: a biological approach. III. Viruses associated with neoplastic conditions. IV. Practical applications.癌症：生物学视角。III. 与肿瘤形成相关的病毒。IV. 实际应用。
Br Med J. 1957 Apr 13;1(5023):841-7. doi: 10.1136/bmj.1.5023.841.
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Studies of thymic function with emphasis on the role of the thymus in oncogenesis.胸腺功能的研究，重点关注胸腺在肿瘤发生中的作用。
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4
A technique for thymectomizing germfree mice.一种对无菌小鼠进行胸腺切除的技术。
J Appl Physiol. 1966 Jan;21(1):279-81. doi: 10.1152/jappl.1966.21.1.279.
5
Acute response of germ-free and conventional mice to ionizing radiation.无菌小鼠和普通小鼠对电离辐射的急性反应。
Arch Pathol. 1968 Dec;86(6):676-80.
6
Increased incidence of spontaneous lung adenomas in mice following neonatal thymectomy.新生期胸腺切除术后小鼠自发性肺腺瘤发病率增加。
Isr J Med Sci. 1971 Jan;7(1):36-41.
7
Radiation-induced lymphopenia. Recovery in thymectomized and splenectomized germ-free mice.
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8
Spontaneous and radiation-related neoplasms in germ-free mice.无菌小鼠中的自发性和辐射相关肿瘤
Arch Pathol. 1972 Sep;94(3):250-4.
9
The concept of immunological surveillance.免疫监视的概念。
Prog Exp Tumor Res. 1970;13:1-27. doi: 10.1159/000386035.
10
Is immunological surveillance not a cell-mediated immune function?
Transplantation. 1974 Jan 1;17(1):135-6.

全身照射对新生期胸腺切除小鼠的影响。良性和恶性肿瘤的发生率。

Effects of whole-body irradiation on neonatally thymectomized mice. Incidence of benign and malignant tumors.

作者信息

Anderson R E, Howarth J L, Troup G M

出版信息

Am J Pathol. 1978 May;91(2):217-27.

PMID:645825
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC2018198/
Abstract

The individual and combined effects of neonatal thymectomy and whole-body irradiation on the prevalence of benign and malignant tumors in germ-free female mice of the Charles Rivers line were studied to determine if a portion of the tumorigenic effects of irradiation can be attributed to injury of the thymic-dependent component of the immune response. Neonatal thymectomy increased a) the incidence of benign and malignant tumors and b) the prevalence of multiple primary neoplasms in an individual mouse. Whole-body exposure to 700 rad at 6 weeks of age further increased th incidence of tumors, but the relative magnitude of this increase was less pronounced than in sham-operated controls. Thus, the cumulative effects of thymectomy plus irradiation are less pronounced than the sum of the individual effects. One of several possible explanations for this observation is that a portion of the carcinogenic effects of whole-body irradiation is mediated by suppression of the thymic-dependent component of the immune response.

摘要

研究了新生期胸腺切除和全身照射对无特定病原体的查尔斯河品系雌性小鼠良性和恶性肿瘤发生率的单独及联合影响，以确定照射致癌效应的一部分是否可归因于免疫反应中胸腺依赖成分的损伤。新生期胸腺切除增加了：a）良性和恶性肿瘤的发生率；b）单个小鼠中多发原发性肿瘤的患病率。6周龄时全身暴露于700拉德进一步增加了肿瘤发生率，但这种增加的相对幅度比假手术对照组要小。因此，胸腺切除加照射的累积效应不如单独效应之和明显。对此观察结果的几种可能解释之一是，全身照射的致癌效应一部分是由免疫反应中胸腺依赖成分的抑制介导的。