钒酸盐对钙离子跨人红细胞膜主动转运的抑制作用。
Vanadate inhibition of active Ca2+ transport across human red cell membranes.
作者信息
Rossi J P, Garrahan P J, Rega A F
出版信息
Biochim Biophys Acta. 1981 Nov 6;648(2):145-50. doi: 10.1016/0005-2736(81)90029-8.
PMID:6458333
Abstract
(1) Vanadate (pentavalent vanadium) inhibits with high affinity (K0.5 = 3 microM) the ATP-dependent Ca2+ efflux in reconstituted ghosts from human red cell. (2) To inhibit Ca2+ efflux vanadate has to have access to the inner surface of the cell membrane (3) The inhibitory effect of vanadate is potentiated by intracellular Mg2+ and by intracellular K+. (4) Ca2+ in the external medium antagonizes the inhibitory effect of vanadate.
摘要
(1) 钒酸盐（五价钒）以高亲和力（K0.5 = 3微摩尔）抑制人红细胞重构膜泡中依赖ATP的Ca2+外流。(2) 为了抑制Ca2+外流，钒酸盐必须能够接触到细胞膜的内表面。(3) 细胞内的镁离子和钾离子会增强钒酸盐的抑制作用。(4) 细胞外介质中的Ca2+会拮抗钒酸盐的抑制作用。
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