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核心技术专利：CN118964589B侵权必究

核心技术专利：CN118964589B侵权必究

Bond G H, Hudgins P M

Biochim Biophys Acta. 1980 Aug 14;600(3):781-90. doi: 10.1016/0005-2736(80)90480-0.

The Mg2+- plus Ca2+-dependent ATPase (Ca2+-ATPase) in human red cell membranes is susceptible to inhibition by low concentrations of vanadate. 2. Several natural activators of Ca2+-ATPase (Mg2+, K+, Na+ and calmodulin) modify inhibition by increasing the apparent affinity of the enzyme for vanadate. 3. Among the ligands tests, K+, in combination with Mg2+, had the most pronounced effect on inhibition by vanadate. 4. Under conditions optimal for inhibition of Ca2+-ATPase, the K 1/2 for vanadate was 1.5 microM and inhibition was nearly complete at saturating vanadate concentrations. 5. There are similarities between the kinetics of inhibition of red cell Ca2+-ATPase and (Na+ + K+)-ATPase prepared from a variety of sources; however, (Na+ + K+)-ATPase is approx. 3 times more sensitive to inhibition by vanadate.

人红细胞膜中的镁离子加钙离子依赖性ATP酶（Ca2+-ATP酶）易受低浓度钒酸盐的抑制。2. 几种Ca2+-ATP酶的天然激活剂（镁离子、钾离子、钠离子和钙调蛋白）通过增加酶对钒酸盐的表观亲和力来改变抑制作用。3. 在测试的配体中，钾离子与镁离子结合对钒酸盐抑制作用的影响最为显著。4. 在抑制Ca2+-ATP酶的最佳条件下，钒酸盐的K1/2为1.5微摩尔，在钒酸盐饱和浓度时抑制作用几乎完全。5. 红细胞Ca2+-ATP酶与从多种来源制备的（钠离子 + 钾离子）-ATP酶的抑制动力学之间存在相似性；然而，（钠离子 + 钾离子）-ATP酶对钒酸盐抑制的敏感性约高3倍。

Bond G H, Hudgins P M

Biochim Biophys Acta. 1980 Aug 14;600(3):781-90. doi: 10.1016/0005-2736(80)90480-0.

The Mg2+- plus Ca2+-dependent ATPase (Ca2+-ATPase) in human red cell membranes is susceptible to inhibition by low concentrations of vanadate. 2. Several natural activators of Ca2+-ATPase (Mg2+, K+, Na+ and calmodulin) modify inhibition by increasing the apparent affinity of the enzyme for vanadate. 3. Among the ligands tests, K+, in combination with Mg2+, had the most pronounced effect on inhibition by vanadate. 4. Under conditions optimal for inhibition of Ca2+-ATPase, the K 1/2 for vanadate was 1.5 microM and inhibition was nearly complete at saturating vanadate concentrations. 5. There are similarities between the kinetics of inhibition of red cell Ca2+-ATPase and (Na+ + K+)-ATPase prepared from a variety of sources; however, (Na+ + K+)-ATPase is approx. 3 times more sensitive to inhibition by vanadate.

人红细胞膜中的镁离子加钙离子依赖性ATP酶（Ca2+-ATP酶）易受低浓度钒酸盐的抑制。2. 几种Ca2+-ATP酶的天然激活剂（镁离子、钾离子、钠离子和钙调蛋白）通过增加酶对钒酸盐的表观亲和力来改变抑制作用。3. 在测试的配体中，钾离子与镁离子结合对钒酸盐抑制作用的影响最为显著。4. 在抑制Ca2+-ATP酶的最佳条件下，钒酸盐的K1/2为1.5微摩尔，在钒酸盐饱和浓度时抑制作用几乎完全。5. 红细胞Ca2+-ATP酶与从多种来源制备的（钠离子 + 钾离子）-ATP酶的抑制动力学之间存在相似性；然而，（钠离子 + 钾离子）-ATP酶对钒酸盐抑制的敏感性约高3倍。