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Biochem J. 1981 May 15;196(2):443-9. doi: 10.1042/bj1960443.
2
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Involvement of the endogenous inhibitor protein in the MgATP-induced inhibition of soluble mitochondrial adenosine triphosphatase activity.内源性抑制蛋白参与MgATP诱导的可溶性线粒体腺苷三磷酸酶活性抑制过程。
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[Direct electric measurement of the functioning of adenosine triphosphatase of submitochondrial particles of beef heart].
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引用本文的文献

1
MgATP-induced inhibition of the adenosine triphosphatase activity of the chloroform-released mitochondrial adenosine triphosphatase.MgATP对氯仿释放的线粒体腺苷三磷酸酶的腺苷三磷酸酶活性的抑制作用。
Biochem J. 1981 May 15;196(2):433-42. doi: 10.1042/bj1960433.
2
Recent developments on structural and functional aspects of the F1 sector of H+-linked ATPases.H⁺ 连接的ATP酶F1 部分结构和功能方面的最新进展。
Mol Cell Biochem. 1984;60(1):33-71. doi: 10.1007/BF00226299.
3
Involvement of the endogenous inhibitor protein in the MgATP-induced inhibition of soluble mitochondrial adenosine triphosphatase activity.内源性抑制蛋白参与MgATP诱导的可溶性线粒体腺苷三磷酸酶活性抑制过程。
Biochem J. 1981 Dec 15;200(3):655-61. doi: 10.1042/bj2000655.

本文引用的文献

1
A NATURALLY OCCURRING INHIBITOR OF MITOCHONDRIAL ADENOSINE TRIPHOSPHATASE.一种天然存在的线粒体腺苷三磷酸酶抑制剂。
J Biol Chem. 1963 Nov;238:3762-9.
2
MgATP-induced inhibition of the adenosine triphosphatase activity of the chloroform-released mitochondrial adenosine triphosphatase.MgATP对氯仿释放的线粒体腺苷三磷酸酶的腺苷三磷酸酶活性的抑制作用。
Biochem J. 1981 May 15;196(2):433-42. doi: 10.1042/bj1960433.
3
Possible regulatory function of a mitochondrial ATPase inhibitor in respiratory chain-linked energy transfer.线粒体ATP酶抑制剂在呼吸链相关能量转移中的潜在调节功能
Biochim Biophys Acta. 1970;205(2):307-11. doi: 10.1016/0005-2728(70)90261-6.
4
The interaction between the mitochondrial ATPase (F 1 ) and the ATPase inhibitor.线粒体ATP酶（F1）与ATP酶抑制剂之间的相互作用。
Biochim Biophys Acta. 1973 Feb 22;292(2):338-49. doi: 10.1016/0005-2728(73)90040-6.
5
Partial resolution of the enzymes catalyzing oxidative phosphorylation. 13. Structure and function of submitochondrial particles completely resolved with respect to coupling factor.催化氧化磷酸化的酶的部分解析。13. 关于偶联因子完全解析的亚线粒体颗粒的结构与功能。
J Biol Chem. 1967 May 25;242(10):2547-51.
6
The activation of mitochondrial particulate ATPase by liposomes of diacylphospholipids.
Biochim Biophys Acta. 1974 Apr 23;347(1):77-86. doi: 10.1016/0005-2728(74)90201-1.
7
Diphosphatidylglycerol-induced changes in the organization of mitochondrial ATPase.
Biochim Biophys Acta. 1974 Sep 20;357(3):333-43. doi: 10.1016/0005-2728(74)90023-1.
8
The equilibrium between the mitochondrial ATPase (F1) and its natural inhibitor in submitochondrial particles.线粒体ATP酶（F1）与其在线粒体亚颗粒中的天然抑制剂之间的平衡。
Biochim Biophys Acta. 1974 May 22;347(2):240-52. doi: 10.1016/0005-2728(74)90048-6.
9
Partial resolution of the enzyme catalyzing oxidative phosphorylation. XXII. Interaction between mitochondrial adenosine triphosphatase inhibitor and mitochondrial adenosine triphosphatase.催化氧化磷酸化的酶的部分解离。XXII. 线粒体腺苷三磷酸酶抑制剂与线粒体腺苷三磷酸酶之间的相互作用。
J Biol Chem. 1970 Mar 25;245(6):1336-44.
10
Studies on oxidative phosphorylation. XV. Latent adenosine 5'-triphosphatase activity of factor A.氧化磷酸化研究。十五。因子A的潜在腺苷5'-三磷酸酶活性。
Arch Biochem Biophys. 1968 Feb;123(2):385-96. doi: 10.1016/0003-9861(68)90149-5.

MgATP对亚线粒体颗粒腺苷三磷酸酶活性的抑制作用。

MgATP-induced inhibition of the adenosine triphosphatase activity of submitochondrial particles.

作者信息

Lowe P N, Beechey R B

出版信息

Biochem J. 1981 May 15;196(2):443-9. doi: 10.1042/bj1960443.

DOI:10.1042/bj1960443
PMID:6459084
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC1163015/
Abstract
  1. The ATP-hydrolytic activity of ox heart submitochondrial particles can be increased from 2-3 mumol/min per mg of protein to 10-12 mumol/min per mg of protein by incubation in media containing 50 mM-Na2B4O7. This process appears to be due to the partial release of inhibitor protein from the particles. 2. The ATPase activity of submitochondrial particles can be inhibited by incubation with the substrate, MgATP. This inhibition is not due to the accumulation of the hydrolysis products, MgADP and Pi, but could involve the process of ATP hydrolysis. 3. The mechanism of MgATP-induced inhibition of ATPase activity is proposed to involve a conformational change in one of the intermediate enzyme species of the ATP-hydrolytic sequence. 4. MgATP inhibits the ATPase activity of control submitochondrial particles at a higher rate and to a greater extent than it does that of inhibitor-protein-depleted submitochondrial particles, suggesting that the conformational change involves the endogenous inhibitor protein.
摘要
  1. 通过在含有50 mM - Na2B4O7的培养基中孵育，牛心亚线粒体颗粒的ATP水解活性可从每毫克蛋白质2 - 3 μmol/分钟提高到每毫克蛋白质10 - 12 μmol/分钟。这个过程似乎是由于抑制剂蛋白从颗粒中部分释放所致。2. 亚线粒体颗粒的ATP酶活性可通过与底物MgATP孵育而受到抑制。这种抑制不是由于水解产物MgADP和Pi的积累，而是可能涉及ATP水解过程。3. 提出MgATP诱导ATP酶活性抑制的机制涉及ATP水解序列中一种中间酶物种的构象变化。4. MgATP对对照亚线粒体颗粒ATP酶活性的抑制速率更高、程度更大，比其对去除抑制剂蛋白的亚线粒体颗粒的抑制作用更强，这表明构象变化涉及内源性抑制剂蛋白。