双膦酸盐对培养的颅骨细胞中前列腺素合成的影响。
Effect of diphosphonates on the synthesis of prostaglandins in cultured calvaria cells.
作者信息
Felix R, Bettex J D, Fleisch H
出版信息
Calcif Tissue Int. 1981;33(5):549-52. doi: 10.1007/BF02409488.
PMID:6459147
Abstract
The calvaria cells cultured for 6 days in the presence of dichloromethanediphosphonate (Cl2MDP) (0.025-250 microM), the synthesis of prostaglandin E2 (PGE2) was inhibited by up to 90%. Inhibition of PGE2 synthesis might be one mechanism whereby this diphosphonate inhibits bone resorption. This effect is not common to all diphosphates since 25 microM 3-amino-1-hydroxypropane-1,1-diphosphonate (AHPDP) stimulated the synthesis of PGE2.
摘要
在二氯甲烷二膦酸盐（Cl2MDP）（0.025 - 250微摩尔）存在的情况下培养6天的颅盖细胞，前列腺素E2（PGE2）的合成被抑制高达90%。PGE2合成的抑制可能是这种二膦酸盐抑制骨吸收的一种机制。这种效应并非所有二膦酸盐都有，因为25微摩尔的3 - 氨基 - 1 - 羟基丙烷 - 1,1 - 二膦酸盐（AHPDP）刺激了PGE2的合成。
Zotero 插件