Hultgren P B, Bove A A
Cardiovasc Res. 1981 Sep;15(9):522-8. doi: 10.1093/cvr/15.9.522.
Chronic volume overload and subsequent left ventricular hypertrophy (LVH) were produced by a surgical shunt between the left subclavian artery and the left atrial appendage in eight dogs. A sham operation was performed on six control dogs. Analysis of biplane ventriculograms showed no significant differences in ejection fraction, mean wall stress, tension-time index, or stress-time index. A significant increase was found in stroke work per gram of left ventricle (P less than 0.005). Myocardial blood flow (MBF) was measured using 9 micrometers, radioactive microspheres at rest, at a constant treadmill workload (CWL) of 2 mph, 2% grade, and at a constant heart rate (CHR) of 175 beats.min-1. Total LVMBF (cm3.min-1) in the shunt dogs was increased at rest (P less than 0.05) with CWL (P less than 0.05) and a CHR (P less than 0.05). However, no differences were found between the groups in the LVMBF.g-1 of myocardium (cm3.g-1.min-1) at rest or during exercise, or in the endocardial to epicardial blood flow ration. Volume overload hypertrophy, without the presence of heart failure, is associated with normal haemodynamic and mechanical function at rest, normal LVMBF.g-1 of myocardium and normal flow distribution at rest and during exercise.
通过在8只狗的左锁骨下动脉和左心耳之间进行外科分流术，制造慢性容量负荷过重及随后的左心室肥厚（LVH）。对6只对照犬进行假手术。双平面心室造影分析显示，射血分数、平均壁应力、张力 - 时间指数或应力 - 时间指数无显著差异。发现每克左心室的搏功显著增加（P小于0.005）。使用9微米放射性微球在静息状态、2英里/小时、2%坡度的恒定跑步机工作量（CWL）以及175次/分钟的恒定心率（CHR）下测量心肌血流量（MBF）。分流犬的总左心室心肌血流量（cm³·min⁻¹）在静息时增加（P小于0.05），在CWL时增加（P小于0.05），在CHR时也增加（P小于0.05）。然而，两组之间在静息或运动时心肌的左心室心肌血流量每克（cm³·g⁻¹·min⁻¹）或心内膜与心外膜血流比值方面未发现差异。容量负荷过重性肥厚在无心力衰竭的情况下，与静息时正常的血流动力学和机械功能、心肌正常的左心室心肌血流量每克以及静息和运动时正常的血流分布相关。
