Barba-Rubio J, Calle-Vélez G, Dominguez-Soto L, Londoño F
J Int Med Res. 1981;9(6):453-8. doi: 10.1177/030006058100900606.
The anti-inflammatory and antimicrobial activities of two topical creams, one containing halcinonide, neomycin and nystatin (HNN), and the other betamethasone valerate, gentamicin, iodochlorhydroxyquin and tolnaftate (BGI), were compared in a randomized, parallel study of 154 patients (eighty-seven secondarily infected eczematous dermatoses; sixty-seven cutaneous candidiasis). Repeated clinical assessments showed that the two creams produced equivalent therapeutic responses both in patients with infected eczematous lesions and candidiasis. HNN and BGI creams eradicated the bacterial pathogens isolated prior to treatment in 80% and 76%, respectively, of the patients with eczematous dermatoses. The organism most frequently isolated in these patients was S. aureus. Local irritation prompting discontinuance of therapy occurred in just one patient receiving HNN, and two patients receiving BGI.
在一项针对154例患者（87例继发性感染性湿疹性皮炎；67例皮肤念珠菌病）的随机平行研究中，比较了两种外用乳膏的抗炎和抗菌活性，一种含有哈西奈德、新霉素和制霉菌素（HNN），另一种含有戊酸倍他米松、庆大霉素、氯碘羟喹和托萘酯（BGI）。反复的临床评估表明，这两种乳膏在感染性湿疹病变和念珠菌病患者中产生了等效的治疗反应。HNN乳膏和BGI乳膏分别使80%和76%的湿疹性皮炎患者治疗前分离出的细菌病原体得到根除。这些患者中最常分离出的病原体是金黄色葡萄球菌。仅1例接受HNN治疗的患者和2例接受BGI治疗的患者因局部刺激而停药。
