Tegler L, Gillquist J, Anderberg B, Lundström B, Johansson H
J Endocrinol Invest. 1981 Jul-Sep;4(3):335-41. doi: 10.1007/BF03349454.
Human thyroid blood flow rate (TBF) was measured during operations by electromagnetic flowmetry in 75 euthyroid patients with normal thyroid tissue, nodular goiter, or solitary adenoma, and in 22 hyperthyroid patients with diffuse or nodular goiter. Blood flow rate was measured in one to four of the thyroid arteries. No difference in blood flow rate was seen between the left and right lobes. The slight difference found between the inferior and superior arteries was not significant. In each subject, total TBF was calculated as 4 times the mean of the recorded blood flow in the single arteries. The total TBF was 31 (9-109) ml/min (inner 95 percentile range) in euthyroid patients, similar in all 3 groups. This is less than in most earlier reports. The relative TBF was 1.2 (0.4-3.8) ml/min/g thyroid tissue in normal thyroid tissue and 0.6 (0.1-3.7) ml/min/g in nontoxic nodular goiter (p less than 0.01). Patients with hyperthyroidism had a higher total TBF 54 (15-197) ml/Min (p less than 0.001), despite preoperative treatment giving euthyroidism, Similar TBF rates were found in 3 hyperthyroid patients given propranolol preoperatively. Electromagnetic flowmetry is applicable to study thyroid blood flow rate. Human TBF shows considerable interindividual variations, which must be kept in mind when studying directly the rate of thyroid hormone secretion from arteriovenous gradients.
在手术过程中，通过电磁血流测定法对75例甲状腺组织正常、患有结节性甲状腺肿或孤立性腺瘤的甲状腺功能正常患者以及22例患有弥漫性或结节性甲状腺肿的甲状腺功能亢进患者的甲状腺血流速率（TBF）进行了测量。在一至四条甲状腺动脉中测量血流速率。左右叶之间的血流速率未见差异。甲状腺下动脉和上动脉之间发现的细微差异不显著。在每个受试者中，总TBF计算为单条动脉记录血流平均值的4倍。甲状腺功能正常患者的总TBF为31（9 - 109）ml/分钟（内部95%百分位数范围），在所有3组中相似。这低于大多数早期报告中的数值。正常甲状腺组织的相对TBF为1.2（0.4 - 3.8）ml/分钟/克甲状腺组织，非毒性结节性甲状腺肿为0.6（0.1 - 3.7）ml/分钟/克（p < 0.01）。甲状腺功能亢进患者的总TBF较高，为54（15 - 197）ml/分钟（p < 0.001），尽管术前治疗使甲状腺功能恢复正常。在术前给予普萘洛尔的3例甲状腺功能亢进患者中发现了相似的TBF速率。电磁血流测定法适用于研究甲状腺血流速率。人体TBF显示出相当大的个体差异，在直接从动静脉梯度研究甲状腺激素分泌速率时必须牢记这一点。
