Kirschbaum B B
Nephron. 1981;29(5-6):205-8. doi: 10.1159/000182368.
The GBM is an important structure for the development of immunologic renal disease. It may serve as the primary antigen or as the site of deposition of immune complexes. The GBM is recognized as the major protein filtration barrier of the glomerulus. The composition of the GBM includes collagen, predominantly but not exclusively type IV, which is present as procollagen. Two glycoproteins, laminin and fibronectin, are either intrinsic components of the GBM or intimately associated with the membrane. Heparan sulfate, a glycosaminoglycan, is contained within the substance of the GBM and seems to comprise the primary anion of the structure. Antibodies to these individual GBM components are being recognized with increasing frequency in patients with glomerulonephritis. The recognition of these antibodies may serve to expand our definition of both immunologic and degenerative diseases of basement membrane.
肾小球基底膜（GBM）是免疫性肾脏疾病发生发展的重要结构。它可能作为主要抗原或免疫复合物的沉积部位。GBM被认为是肾小球的主要蛋白质滤过屏障。GBM的组成包括胶原蛋白，主要但并非仅为IV型，以原胶原蛋白形式存在。两种糖蛋白，层粘连蛋白和纤连蛋白，要么是GBM的固有成分，要么与该膜紧密相关。硫酸乙酰肝素，一种糖胺聚糖，包含在GBM物质中，似乎构成了该结构的主要阴离子。在肾小球肾炎患者中，针对这些GBM单个成分的抗体被越来越频繁地识别出来。对这些抗体的认识可能有助于扩展我们对基底膜免疫性和退行性疾病的定义。
