Shinohara H
Experientia. 1981 Dec 15;37(12):1353-4. doi: 10.1007/BF01948407.
Fragmentation of oocytes was induced in the ovary, via ovulation suppression, by administration of dehydroepiandrosterone acetate (DHA-Ac) to mature cycling rats. The maximal fragmentation ratio, 15.0 +/- 3.2%, was obtained by 10 mg/100 g b.wt/day for 7-day administration of DHA-Ac. The relationship of fragmentation to the first stage of meiosis is also discussed.
通过对成熟的性周期大鼠施用醋酸脱氢表雄酮(DHA-Ac)来抑制排卵,从而在卵巢中诱导卵母细胞碎片化。通过以10mg/100g体重/天的剂量连续7天施用DHA-Ac,获得了最大碎片化率,即15.0±3.2%。本文还讨论了碎片化与减数分裂第一阶段的关系。