8-羟基-2-（二正丙基氨基）四氢萘，一种新型中枢作用的5-羟色胺受体激动剂。 - Suppr

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超能文献

8-Hydroxy-2-(di-n-propylamino)tetralin, a new centrally acting 5-hydroxytryptamine receptor agonist.

作者信息

Arvidsson L E, Hacksell U, Nilsson J L, Hjorth S, Carlsson A, Lindberg P, Sanchez D, Wikstrom H

出版信息

J Med Chem. 1981 Aug;24(8):921-3. doi: 10.1021/jm00140a002.

DOI:10.1021/jm00140a002

PMID:6460101

Abstract

摘要

相似文献

8-Hydroxy-2-(di-n-propylamino)tetralin, a new centrally acting 5-hydroxytryptamine receptor agonist.8-羟基-2-（二正丙基氨基）四氢萘，一种新型中枢作用的5-羟色胺受体激动剂。

J Med Chem. 1981 Aug;24(8):921-3. doi: 10.1021/jm00140a002.

(+)-cis-8-Hydroxy-1-methyl-2-(di-n-propylamino)tetralin: a potent and highly stereoselective 5-hydroxytryptamine receptor agonist.（+）-顺式-8-羟基-1-甲基-2-（二正丙基氨基）四氢萘：一种强效且高度立体选择性的5-羟色胺受体激动剂。

J Med Chem. 1987 Nov;30(11):2105-9. doi: 10.1021/jm00394a029.

N,N-di-n-propylserotonin: binding at serotonin binding sites and a comparison with 8-hydroxy-2-(di-n-propylamino)tetralin.

J Med Chem. 1988 Apr;31(4):867-70. doi: 10.1021/jm00399a031.

Testosterone increases the concentration of [3H]8-hydroxy-2-(di-n-propylamino)tetralin binding [corrected] at 5-HT1A receptors in the medial preoptic nucleus of the castrated male rat.睾酮可提高去势雄性大鼠内侧视前核中5-HT1A受体处[3H]8-羟基-2-（二正丙基氨基）四氢萘结合[校正后]的浓度。

Eur J Pharmacol. 1990 Jun 8;181(3):329-31. doi: 10.1016/0014-2999(90)90101-b.

Occurrence and pharmacological significance of metabolic ortho-hydroxylation of 5- and 8-hydroxy-2-(di-n-propylamino)tetralin.5-和8-羟基-2-（二正丙基氨基）四氢萘代谢邻位羟基化的发生及其药理学意义。

J Med Chem. 1988 Jun;31(6):1080-4. doi: 10.1021/jm00401a005.

The putative serotonin receptor agonist 8-hydroxy-2-(di-n-propylamino)tetralin antagonizes the antinociceptive effect of morphine.假定的血清素受体激动剂8-羟基-2-（二正丙基氨基）四氢化萘可拮抗吗啡的镇痛作用。

Neurosci Lett. 1985 Feb 28;54(1):71-5. doi: 10.1016/s0304-3940(85)80120-8.

Structural factors of importance for 5-hydroxytryptaminergic activity. Conformational preferences and electrostatic potentials of 8-hydroxy-2-(di-n-propylamino)tetralin (8-OH-DPAT) and some related agents.对5-羟色胺能活性重要的结构因素。8-羟基-2-（二正丙基氨基）四氢萘（8-OH-DPAT）及一些相关药物的构象偏好和静电势。

J Med Chem. 1988 Jan;31(1):212-21. doi: 10.1021/jm00396a034.

125I-Bolton-Hunter-8-methoxy-2-[N-propyl-N-propylamino]tetralin as a new selective radioligand of 5-HT1A sites in the rat brain. In vitro binding and autoradiographic studies.

J Pharmacol Exp Ther. 1988 Feb;244(2):751-9.

[3H]8-hydroxy-2-(di-n-propylamino)tetralin binding to pre- and postsynaptic 5-hydroxytryptamine sites in various regions of the rat brain.[3H]8-羟基-2-（二正丙基氨基）四氢萘与大鼠脑不同区域突触前和突触后5-羟色胺位点的结合

J Neurochem. 1985 Jun;44(6):1685-96. doi: 10.1111/j.1471-4159.1985.tb07155.x.

[125I-BH-8-MeO-N-PAT, a new ligand for the study of 5-HT1A receptors in the central nervous system].

C R Acad Sci III. 1988;306(4):147-52.

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