Walsh S Z
J Ment Defic Res. 1981 Dec;25 Pt 4:243-51. doi: 10.1111/j.1365-2788.1981.tb00114.x.
The records of 469 institutionalised mentally retarded subjects were examined. Keratoconus and blindness were present in 8 per cent and 4 per cent of the ninety-one subjects with Down syndrome. Only one case of keratoconus was found among the 378 subjects with mental deficiency of other aetiology. The incidence of strabismus, nystagmus and cataract was also increased in subjects with Down syndrome, especially in females. Cases of acute keratoconus associated with Down syndrome reported in the world literature are summarised. A total of about forty cases has ben reported between the ages of nine and fifty-three years. Sight has been preserved equally well after both conservative management and keratoplasty in eyes with and without cataracts.
对469名机构收容的智力迟钝受试者的记录进行了检查。在91名唐氏综合征患者中，圆锥角膜和失明的发生率分别为8%和4%。在378名其他病因导致智力缺陷的受试者中，仅发现1例圆锥角膜。唐氏综合征患者斜视、眼球震颤和白内障的发生率也有所增加，尤其是女性。总结了世界文献中报道的与唐氏综合征相关的急性圆锥角膜病例。总共报告了约40例，年龄在9岁至53岁之间。无论有无白内障，采用保守治疗和角膜移植术后，视力均得到了同样良好的保留。
