Capitanio A, Ponticelli C, D'Angelo A, Mannucci P M
Proc Eur Dial Transplant Assoc. 1981;18:375-9.
Forty-six transplant patients had lower platelet serotonin and higher plasma beta-thromboglobulin (beta-TG) than normal controls. These abnormalities were more pronounced in acute rejection (AR) than in chronic rejection (CR), but were also present in normally functioning transplants (FT). Patients also showed lower serum levels of thromboxane B2 (TxB2) than controls. Plasma fibrinopeptide A (FPA) was higher in AR, but not in CR and in FT, than in controls. Therefore, in renal transplant recipients, platelets continue to circulate after in vivo activation, the abnormalities being roughly proportional to the extent of graft injury. Granule-bound substances secreted into the circulation might produce ischaemia and platelet aggregates, damaging the graft and aggravating the rejection lesions.
46名移植患者的血小板血清素水平低于正常对照组，血浆β-血小板球蛋白（β-TG）水平高于正常对照组。这些异常在急性排斥反应（AR）中比慢性排斥反应（CR）中更明显，但在功能正常的移植物（FT）中也存在。患者的血栓素B2（TxB2）血清水平也低于对照组。AR患者的血浆纤维蛋白肽A（FPA）水平高于对照组，而CR和FT患者则与对照组无差异。因此，在肾移植受者中，血小板在体内激活后仍继续循环，异常情况大致与移植物损伤程度成正比。分泌到循环中的颗粒结合物质可能会产生局部缺血和血小板聚集，损害移植物并加重排斥病变。
