Lenhard V, Diehm H, Rettwitz W, Dreikorn K
Proc Eur Dial Transplant Assoc. 1981;18:433-8.
The prognostic significance of different types of pretransplant anti-donor B cell antibodies on graft outcome was studied in 193 cadaver kidney recipients. Additionally, in 84 combinations the MLR inhibitory activity of patient sera was determined, and the relationship of pretransplant anti-donor B cell antibodies, MLR inhibitory activity in graft outcome was analysed. Graft survival was high in recipients with cold B cell antibodies, whereas it was unfavourable in recipients positive for warm B cell antibodies. MLR inhibitory activity was highly correlated with the latter type of antibody. In patients with high pretransplant MLR inhibitory activity graft outcome was significantly impaired. In recipients wild cold-reactive B cell antibodies who had excellent graft outcome, MLR inhibitory activity was not demonstrable.
在193例尸体肾移植受者中研究了不同类型的移植前抗供体B细胞抗体对移植物转归的预后意义。此外，在84组样本中测定了患者血清的混合淋巴细胞反应（MLR）抑制活性，并分析了移植前抗供体B细胞抗体、MLR抑制活性与移植物转归之间的关系。冷反应性B细胞抗体阳性的受者移植物存活率较高，而温反应性B细胞抗体阳性的受者移植物存活率则较低。MLR抑制活性与后一种抗体高度相关。移植前MLR抑制活性高的患者移植物转归明显受损。在移植物转归良好的冷反应性B细胞抗体阳性受者中，未检测到MLR抑制活性。
