缅甸的人类遗传学

Human genetics in Burma.

作者信息

Kyu H, Thu A, Cook P J

出版信息

Hum Hered. 1981;31(5):291-5. doi: 10.1159/000153225.

Abstract

Contrary to earlier reports from Asia, trisomy 21 is common in Burma and other chromosome abnormalities are found. A variety of dominant, recessive and X-linked genetic disorders occur. Twins are found in 1% of births and MZ and DZ twins are equally common. Thalassaemia and meningomyelocele are relatively common while congenital dislocation of the hip and phenylketonuria are very rare. The intensity of inbreeding had been measured by survey and found to be F = 0.0005 in Rangoon and F = 0.0015 in villages around Hlegu.

摘要

与亚洲早期报告相反，21三体综合征在缅甸很常见，且发现了其他染色体异常情况。出现了多种显性、隐性和X连锁遗传病。双胞胎在1%的出生人口中出现，同卵双胞胎和异卵双胞胎出现的几率相同。地中海贫血和脊髓脊膜膨出相对常见，而先天性髋关节脱位和苯丙酮尿症则非常罕见。通过调查测量了近亲繁殖强度，发现仰光的近亲繁殖系数F = 0.0005，在Hlegu周围村庄的近亲繁殖系数F = 0.0015。