Abrahamsson L, Hackl H
Maturitas. 1981 Dec;3(3-4):225-34. doi: 10.1016/0378-5122(81)90029-3.
53 patients from a mainly climacteric population were treated monthly with 200 mg dehydroepiandrosterone (DHEA) oenanthate or with 1 ampoule Gynodian-Depot. Pronounced adiposity was present in 15 of these cases. Hormonal variables were determined before the treatment and during the depot effect of the preparations in order to study the principle which supports the oestrogenic influence and any weight-reducing influence under administration of DHEA. The elimination of low-polar oestrogens increased considerably in 4 out of 13 post-menopausal cases treated with DHEA. This effect is probably indirect and presupposes intact ovaries. The incorporation of exogenous DHEA into the excretion of 17-ketosteroids and of 17-ketogenic steroids, such as those of androsterone + aethio-cholanolone, depends on the size of the initial pool inasmuch as it is higher in small initial pools than in saturated pools- the size of the pool being age-dependent. An average weight loss of greater than 1 kg/mth was observed under DHEA treatment in 7 out of 15 adipose cases. In comparison to the other 8 adipose cases, these 7 were younger and therefore also displayed higher values for 17-ketosteroids and their individual fractions. These circumstances appeared to explain why the administration of DHEA resulted in higher levels of free plasma DHEA which, in contrast to the cases without loss of weight, also resulted in an increase of renal DHEA-sulphate clearance. It was concluded from the findings that this is the explanation for the catabolic effect of exogenous DHEA. Post-menopausally increased FSH and LH fractions were markedly suppressed in about half of the determinations after Gynodian-Depot administration, the findings indicating that DHEA is probably involved in suppression of the LH fraction.
对53名主要处于更年期的患者每月进行一次治疗，分别给予200毫克庚酸脱氢表雄酮（DHEA）或1支复方孕二烯酮长效注射剂。这些病例中有15例存在明显肥胖。在治疗前以及制剂的长效作用期间测定激素变量，以研究支持雌激素影响的原理以及在DHEA给药情况下的任何减重影响。在13例接受DHEA治疗的绝经后病例中，有4例低极性雌激素的消除显著增加。这种作用可能是间接的，并且以完整的卵巢为前提。外源性DHEA纳入17 - 酮类固醇和17 - 生酮类固醇（如雄酮+乙基胆烷醇酮）的排泄，取决于初始池的大小，因为在小初始池中比在饱和池中更高，池的大小与年龄有关。在15例肥胖病例中，有7例在DHEA治疗下观察到平均每月体重减轻超过1千克。与其他8例肥胖病例相比，这7例更年轻，因此17 - 酮类固醇及其各个组分的值也更高。这些情况似乎解释了为什么给予DHEA会导致游离血浆DHEA水平升高，与未减重的病例相比，这也导致肾DHEA - 硫酸盐清除率增加。从这些发现得出的结论是，这就是外源性DHEA分解代谢作用的解释。在给予复方孕二烯酮长效注射剂后的大约一半测定中，绝经后升高的促卵泡生成素（FSH）和促黄体生成素（LH）组分被显著抑制，这些发现表明DHEA可能参与了LH组分的抑制。
