Eskenasy A
Morphol Embryol (Bucur). 1981 Jul-Sep;27(3):231-8.
A series of 142 bronchial carcinoids studied on repeated endoscopic biopsies and surgical specimens (mostly lobectomies) was revised in order to distinguish the cases in which an increasing malignancy occurred and evolved up to the transformation into lung carcinomas. Twenty-one cases (14.79 per cent) were marked out (Table 1), of which ten were atypical carcinoids with increasing nuclear anaplasia (hyperchromaticity, pleomorphic and monstrous nuclei, prominent nucleoli), mitoses, sometimes presence of intracytoplasmic keratin granules, etc.; three of these cases presented liver, lymph node or rib metastases with histotypical structures. Ten bronchial carcinoids were carcinomatously transformed: four cases were macrocellular (large cell anaplastic) carcinomas, two other epidermoid ones and four became cylindrocubic carcinomas: all these malignantly transformed carcinoids presented transition areas between the carcinoid and the carcinomatous structures. In a last case, the bronchial carcinoid coexisted with a macrocellular carcinoma developed extrabronchially without overt structural relationships. None of the investigated cases became a macrocellular (oat cell) carcinoma.
对142例经反复内镜活检及手术标本（大多为肺叶切除术）研究的支气管类癌进行了回顾，以区分那些恶性程度增加并发展至转变为肺癌的病例。确定了21例（14.79%）（表1），其中10例为非典型类癌，核间变增加（核深染、核多形性及怪异核、核仁明显）、有丝分裂，有时存在胞质内角蛋白颗粒等；其中3例出现肝、淋巴结或肋骨转移，具有典型组织学结构。10例支气管类癌发生了癌变：4例为大细胞（大细胞间变）癌，另外2例为表皮样癌，4例变为圆柱立方细胞癌：所有这些恶性转化的类癌在类癌和癌结构之间均呈现移行区。在最后1例中，支气管类癌与1例在支气管外发生的大细胞癌共存，二者无明显结构关系。所研究的病例均未转变为大细胞（燕麦细胞）癌。
